Professor Paul KS Chan is Professor of the Department of Microbiology at the Faculty of Medicine of The Chinese University of Hong Kong, and Honorary Consultant in Microbiology for the New Territories East Cluster Hospitals of the Hong Kong Hospital Authority.

Professor Chan is a renowned clinical virologist with special interests in viral epidemiology, pathogenesis and oncogenesis. He has published eight book chapters and more than 200 research papers on clinical virology.

Professor Chan gives imperative advices to the Hong Kong Government. He is the Vice-Chairman of the Scientific Committee on Emerging and Zoonotic Diseases of the Centre for Health Protection; and is a member of the Grant Review Board for the Research Fund for the Control of Infectious Diseases, Human Papillomavirus Vaccine Working Group, Hospital Authority Avian Influenza Working Group, and Examiner Committee of the Hong Kong College of Pathologists. Professor Chan also serves a number of international professional bodies including the Asia-Pacific Advisory Committee on Influenza, Asia-Pacific Advisory Committee on Prevention of Cervical Cancer, GlaxoSmithKline Seasonal Influenza Global Advisory Board, as well as short-term consultant for the World Health Organization on influenza.

• Viral Oncology
  To study the epidemiology and pathogenesis of viral infections that are associated with human cancers. Our present lines of research include the role of novel human herpesviruses (human herpesvirus types six, seven and eight) in the development of human cancers; the molecular mechanisms of human papillomaviruses in causing cervical cancer; the potential clinical applications of using human papillomavirus DNA detection in screening and post-treatment surveillance for cervical cancer.
  
• Viral Epidemiology
  To study viral infections at a population level. Our recent studies include the disease impact and seasonal variation of rotavirus (the most important cause of diarrhea in infants) and respiratory syncytial virus (the most important cause of lower respiratory tract in young children).
  
• Opportunistic Viral Infections
  To study the clinical presentations, rapid diagnostic methods and pathogenesis of viral infections that attack immunocompromised patients. Our recent research mainly concentrates on the clinical significance of human herpesvirus six, human herpesvirus seven, human herpesvirus eight and TT virus in bone marrow and renal transplant recipients.
  

Journal or Magazine Article

• Chan PKS, Ho WCS, Wong MCS, Chang AR, Chor JSY, Yu MY. Epidemiologic risk profile of infection with different groups of human papillomaviruses. Journal of Medical Virology 2009;81:1635–1644
• Lee N, Chan PKS, Hui DSC, Rainer TH, Wong E, Choi KW, Lui GCY, Wong BCK, Wong R, Lam WY, Chu IMT, Lai RWM, Cockram CS, Sung JY. Viral loads and duration of viral shedding in adult patients hospitalized with influenza. Journal of Infectious Diseases 2009;200:492–500
• Chan MCW, Lee N, Chan PKS, Leung TF, Sung JJY. Fecal detection of influenza A virus in patients with concurrent respiratory and gastrointestinal symptoms. Journal of Clinical Virology 2009;45:208-211
• Chan PKS . A review on human influenza A H5N1 infections in Hong Kong. Sci China Ser C-Life Sci 2009; 52: 412-418
• Lam WY , Chan RCW, Sung JJY, Chan PKS. Genotype distribution and sequence variation of hepatitis E virus, Hong Kong. Emerging Infectious Diseases 2009; 15: 792-794.
• Li CSY, Chan PKS, Tang JW. Molecular epidemiology of hepatitis C genotype 6a from patients with chronic hepatitis C from Hong Kong. Journal of Medical Virology 2009;81:628-633
• Yeo W, Chan T, Leung NWY, Lam WY, Mo FKF, Chu MT, Chan HLY, Hui EP, Let KIK, Mok TSK, Chan PKS. Hepatitis B virus reactivation in lymphoma patients with prior resolved hepatitis B undergoing anticancer therapy with or without Rituximab. Journal of Clinical Oncology 2009;27:605-611
• Chan PKS, Luk ACS, Luk TNM, Lee KF, Cheung JLK, Ho KM, Lo KK. Distribution of human papillomavirus types in anogenital warts of men. Journal of Clinical Virology 2009;44:111-114
• Cheung JLK, Cheung TH, Ng CWY, Yu MY, Wong MCS, Siu SSN, Yim SF, Chan PKS. Analysis of HPV18 Viral Load and Integration Status from Low-Grade Cervical Lesion to Invasive Cervical Cancer. Journal of Clinical Microbiology 2009:47:287-293
• Sung RYT, Chan PKS, T Tsen,  AM Li, WY Lam, ACM Yeung, EAS Nelson.  Identification of Viral and Atypical Bacterial Pathogens in Children Hospitalized With Acute Respiratory Infections in Hong Kong by Multiplex PCR Assays. Journal of Medical Virology 2009;81:153–9.
• WY Lam, Julian W Tang, Apple CM Yeung, Lawrence CM Chiu, Joseph JY Sung, Paul KS Chan. Avian Influenz a virus A/HK/483/97 (H5N1) NS1 protein induces apoptosis in human airway epithelial cells. Journal of Virology Mar 2008; 82(6):2741-2751
• N Lee, CK Wong, PKS Chan, SWM Lun, G Lui, B Wong, DSC Hui, CWK Lam, CS Cockram, KW Choi, ACM Yeung, JW Tang, JJY Sung. Hypercytokinermia and Hyperactivation of phosphor-p38 mitogen-activated protein kinase in severe human influenza A virus infection. Clinical Infectious Diseases Sept 15 2007; 45:723-731
• Julian W Tang Ka Fai To, Anthony WI Lo, Joseph J Sung, HK Ng, Paul KS Chan. Quantitative temporal-spatial distribution of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) in post-mortem tissues. Journal of Medical Virology 2007; 79:1245-1253
• Chan MC, Sung JJ, Lam RK, Chan PK , Lai RW, Leung WK. Sapovirus detection by quantitative real-time RT-PCR in clinical stool specimens. J Virol Methods Jun 2006; 134(1-2):146-153
• Poccia F, Agrati C, Castilletti C, Bordi L, Gioia C, Horejsh D, Ippolito G, Chan PK, Hui DS, Sung JJ, Capobianchi MR, Malkovsky M. Anti-Severe Acute Respiratory Syndrome Coronavirus Immune Responses: The Role Played by V gamma 9V delta 2 T Cells. J Infect Dis 2006; 193:1244-1249
• Hui DS, Ip M, Tang JW, Wong AL, Chan MT, Hall SD, Chan PK, Sung JJ. Airflows around oxygen masks: A potential source of infection? Chest 2006; 130:822-826
• Nelson Leung Sang Tang, Paul Kay Sheung Chan , Chun Kwok Wong, Ka Fai To, Alan Ka Lun Wu, Ying Man Sung, David Shu Cheong Hui, Joseph Jao Yiu Sung, and Christopher Wai Kei Lam. Early Enhanced Expression of Interferon-Inducible Protein-10 (CXCL-10) and Other Chemokinees Predicts Adverse Outcome in Severe Acute Respiratory Syndrome. Clinical Chemistry 2005; 51:12:2333-2340
• KC Allen Chan, Nelson LS Tang, David SC Hui, Grace TY Chung, Alan KL Wu, Stephen SC Chim, Rossa WK Chiu, Nelson Lee, KW Choi, YM Sung, Paul KS Chan, YK Tong, ST Lai, WC Yu, Owen Tsang and YM Dennis Lo. Absence of association between angiotensin converting enzyme polymorphism and development of adult respiratory distress syndrome in patients with severe acute respiratory syndrome: a case control study. BMC Infectious Diseases 2005, 5:26
• Grace TY Chung, Rossa WK Chiu, Jo LK Cheung, Yongjie Jin, Stephen SC Chim, Paul KS Chan and YM Dennis Lo. A simple and rapid approach for screening of SARS-coronavirus genotypes: an evaluation study. BMC Infectious Diseases 2005, 5:87
• Paul KS Chan, Pak Leong Lim, Esther YM Liu, Jo LK Cheung, Danny TM Leung, Joseph JY Sung. Antibody avidity maturation during severe acute respiratory syndrome-associated coronavirus infection. Journal of Infectious Diseases July 2005; 192(1):166-169
• Patrick T. W. Law, Chi-Hang Wong, Thomas C.C. Au, Chi-Pang Chuck, Siu-Kai Kong, Paul K.S. Chan , Ka-Fai To, Anthony W.I. Lo, Judy Y.W. Chan, Yick Keung Suen, H.Y. Edwin Chan, Kwok Pui Fung, Mary M.Y. Waye, Joseph J.Y. Sung, Y.M. Dennis Lo and Stephen K.W. Tsui. The 3a protein of severe acute respiratory syndrome-associated coronavirus induces apoptosis in Vero E6 cells. Journal of General Virology 2005; 86: 1921-1930
• Nelson Lee. K.C. Allen Chan, David S. Hui, Enders K.O. Ng, Alan Wu, Rossa W.K. Chiu, Vincent W.S. Wong, Paul K.S. Chan, K.T. Wong, Eric Wong, C.S. Cockram, John S. Tam, Joseph J.Y. Sung, Y.M. Dennis Lo. Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients. Journal of Clinical Virology 2004; 31:304-309
• Man SY, Lee N, Ip M, Antonio GE, Chau SSL, Mak P Graham, CA Zhang, M Liu G, Chan PKS, Ahuja AT, Hui D, Sung JJY, and Rainer TH. Prospective comparison of three predictive rules for assessing severity of community acquired pneumonia in Hong Kong. Thorax April 2007; 62:348-353
• Julian W. Tang, Jo L. K. Cheung, Ida M. T. Chu, Joseph J. Y. Sung, Malik Peiris, and Paul K. S. Chan. The Large 386-nt Deletion in SARS-Associated Coronavirus: Evidence for Quasispecies? Journal of Infectious Diseses 15 Sep 2006; 194:808-813
• DTM Leung, WWC van Maren, FKL. Chan, WS Chan, AWI Lo, CH Ma, FCH. Tam, KF To, PKS Chan, JJY Sung, and PLLim. Extremely Low Exposure of a Community to Severe Acute Respiratory Syndrome Coronavirus; False Seropositivity due to Use of Bacterially Derived Antigens. Journal of Virology Sep 2006; 80(18):8920-8928